Design and Application of Chitosan/biphasic Calcium Phosphate Porous Scaffolds for Bone Tissue Engineering
Sendemir-Urkmez, Aylin
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https://hdl.handle.net/2142/82798
Description
Title
Design and Application of Chitosan/biphasic Calcium Phosphate Porous Scaffolds for Bone Tissue Engineering
Author(s)
Sendemir-Urkmez, Aylin
Issue Date
2006
Doctoral Committee Chair(s)
Russell D. Jamison
Department of Study
Materials Science and Engineering
Discipline
Materials Science and Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Biomedical
Language
eng
Abstract
Cell loaded tissue engineered constructs were produced in vitro at clinically relevant sizes and implanted with and without bFGF into a porcine mandibular defect model. Tissue engineered constructs facilitated the healing of mandibular defects only if combined with delivery of bFGF via gelatin microspheres. bFGF release from the constructs improved neovascularization in the defect area and subsequently enhanced new bone formation. Although the rate and extent of bone formation was similar in bFGF group to those in empty defects for the period of the study, existence of woven bone in bFGF group suggests that bone formation is continuing while the lamellar structure in empty defects indicates that bone formation in that group was finalized.
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