Developmental Cell Death and Androgens Affect Neuron Number in the Primary Visual Cortex of Male and Female Rats
Nunez, Joseph Luis
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Permalink
https://hdl.handle.net/2142/82546
Description
Title
Developmental Cell Death and Androgens Affect Neuron Number in the Primary Visual Cortex of Male and Female Rats
Author(s)
Nunez, Joseph Luis
Issue Date
2000
Doctoral Committee Chair(s)
Juraska, Janice M.
Department of Study
Neuroscience
Discipline
Neuroscience
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
Finally, I investigated the effect of neonatal hormone manipulations (females + estradiol, females + DHT) upon cell death in the developing rat posterior cortex. DHT implantation in females decreased the proportion of cells dying relative to control females (similar to control males), while estrogen implantation in females failed to alter cell death relative to control females. Thus, androgens are responsible for greater cell survival in the developing cortex.
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