University of Illinois Urbana-Champaign

Functional Peptidomics: Combining Discovery-Based Mass Spectrometry and Neurophysiology to Explore Communication of Phase -Resetting Cues in the Rat Suprachiasmatic Nucleus

Atkins, Norman, Jr

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https://hdl.handle.net/2142/82529

Description

Title
Functional Peptidomics: Combining Discovery-Based Mass Spectrometry and Neurophysiology to Explore Communication of Phase -Resetting Cues in the Rat Suprachiasmatic Nucleus
Author(s)
Atkins, Norman, Jr
Issue Date
2009
Doctoral Committee Chair(s)
Martha L. Gillette
Department of Study
Neuroscience
Discipline
Neuroscience
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Physiology
Language
eng
Abstract
This thesis justifies functional peptidomics as a useful approach to understanding intercellular signaling mechanisms regulating SCN clock phase. Directly detecting dynamic release properties of peptides from the SCN brain slice provides new insights on a complex phenomenon phenomenon. The identification and characterization of little SAAS serves as an example of the facets of SCN physiology left to be discovered. Utilization of peptidomics strategies will significantly advance understanding of timing homeostatic mechanisms.
Graduation Semester
2009
Type of Resource
text
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http://hdl.handle.net/2142/82529

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Dissertations - Neuroscience