Interactions Between Polyethylene Glycol Chains and Proteins and Chemically Selective Surfaces
Sheth, Shailesh Rameshchandra
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https://hdl.handle.net/2142/82474
Description
Title
Interactions Between Polyethylene Glycol Chains and Proteins and Chemically Selective Surfaces
Author(s)
Sheth, Shailesh Rameshchandra
Issue Date
1999
Doctoral Committee Chair(s)
Deborah Leckband
Department of Study
Chemical Engineering
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Physical
Language
eng
Abstract
The results presented in this work directly demonstrate that far from presenting an inert and repulsive steric barrier, PEG brushes can interact differently with different chemically selective surfaces. Clearly, PEG is not an inert, simple polymer whose biological activity, especially, vis-a-vis proteins, can be solely described via descriptions of 'simple' polymers such as the excluded volume or scaling theory. Rather, these studies show that its biological response is coupled to the specific physico-chemical attributes of its segments and hence, to the competitive interactions between the solvent and other entities such as non-polar groups on the protein surface for the chain segments.
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