Phase Inversion Dynamics of Polylactic Glycolic Acid Solutions Related to Biopharmaceutical Drug Delivery
Brodbeck, Kevin J.
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https://hdl.handle.net/2142/82471
Description
Title
Phase Inversion Dynamics of Polylactic Glycolic Acid Solutions Related to Biopharmaceutical Drug Delivery
Author(s)
Brodbeck, Kevin J.
Issue Date
1999
Doctoral Committee Chair(s)
McHugh, Anthony J.
Department of Study
Chemical Engineering
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Pharmacy
Language
eng
Abstract
Protein burst on injection was entirely eliminated when the protein particle was densified with stearic acid and placed in a slow phase-inverting depot formulation. Particle densification can potentially be used with any protein or highly soluble drug agent, unlike other techniques that are protein specific. Taking advantage of the effects of low aqueous affinity and densification, a PLGA solution depot was produced that sustained serum hGH levels in normal rats at 10 to 200 ng/mL for 28 days.
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