Microfluidic Platforms for Investigating Cell Migration
Silvestre, Jonathan
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Permalink
https://hdl.handle.net/2142/82414
Description
Title
Microfluidic Platforms for Investigating Cell Migration
Author(s)
Silvestre, Jonathan
Issue Date
2008
Doctoral Committee Chair(s)
Leckband, Deborah E.
Kenis, Paul J.A.
Department of Study
Chemical Engineering
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Chemical
Language
eng
Abstract
Furthermore, these studies quantified the relative effects of E-cadherin expression and adhesive ligation on the migration velocities of mammary breast tumor cells. Micropatterned proteins were used to titrate the relative effects of E-cadherin and Fibronectin on the migration velocities of the metastatic mammary epithelial tumor cells MDA-MB-231. These investigations show that increased E-cadherin expression reduces cell motility by both adhesion-dependent and adhesion-independent mechanisms. By controlling both the substratum composition and E-cadherin expression we defined conditions that favor either the adhesion-independent or the adhesion-dependent mechanism of motility suppression.
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