Regulation of Homophilic and Heterophilic Adhesion Among Classical Cadherins
Lee, Keng Jin
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https://hdl.handle.net/2142/82413
Description
Title
Regulation of Homophilic and Heterophilic Adhesion Among Classical Cadherins
Author(s)
Lee, Keng Jin
Issue Date
2008
Doctoral Committee Chair(s)
Leckband, Deborah E.
Department of Study
Chemical Engineering
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Chemical
Language
eng
Abstract
Finally, fluorescence imaging assessed cadherin clustering and actin organization in E-cadherin expressing cells cultured on E-, N-, and C-cadherin ectodomains. As expected, the formation of filamentous actin correlated with the Rac activation amplitudes in E-cadherin expressing cells. The results also showed that lateral cadherin clustering, which is thought to be an initial response to cadherin ligation, occurs in E-cadherin expressing cells as a result of both heterophilic and homophilic binding. However, I also showed that lateral cadherin clustering is not a cadherin-specific response. These results are important because they suggest that cadherin-dependent differences in intracellular signaling may play a greater role in cell sorting than the biophysical properties of bonds between ectodomain subtypes.
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