Microblood Analyzers for the Sensitive and Portable Detection of Clinically Relevant Cardiac Markers
Larsen, Robert T.
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https://hdl.handle.net/2142/82403
Description
Title
Microblood Analyzers for the Sensitive and Portable Detection of Clinically Relevant Cardiac Markers
Author(s)
Larsen, Robert T.
Issue Date
2007
Doctoral Committee Chair(s)
Masel, Richard I.
Department of Study
Chemical Engineering
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Chemical
Language
eng
Abstract
A laminar tube flow with 1st order wall reaction model was used for the cFABP microdevice assay, which could predict assay behavior for a range of conditions. The pseudo-first order reaction rate was estimated at ∼1.5x10-6 m/s, and it was determined that a 40 mum wide channel operated in the desirable reaction rate limited regime, rather than the undesirable mass transfer limited regime of conventional heterogeneous immunoassays. The model also provided reasonable estimates of assay sensitivity (0.5 pg/mL--600 pg/mL depending on the assay parameters).
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