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https://hdl.handle.net/2142/82389
Description
Title
Microfluidics for Biomolecular Studies
Author(s)
Toepke, Michael W.
Issue Date
2006
Doctoral Committee Chair(s)
Kenis, Paul J.A.
Department of Study
Chemical and Biomolecular Engineering
Discipline
Chemical and Biomolecular Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Chemical
Language
eng
Abstract
Large-scale integrated microfluidic networks were designed and fabricated in order to carry out large combinatorial synthesis and screening. The microfluidic devices contained a series of small chambers with a total volume of one nanoliter to contain each of the combinations in the screening library. The library screen was carried out using a label-free sensor that was integrated into the microfluidic device. The sensor identified strongly binding ligands in a combinatorial screen of antibodies.
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