Homophilic and Heterophilic Interactions Among Cadherin Cell Adhesion Molecules
Prakasam, Anil Kumar
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https://hdl.handle.net/2142/82377
Description
Title
Homophilic and Heterophilic Interactions Among Cadherin Cell Adhesion Molecules
Author(s)
Prakasam, Anil Kumar
Issue Date
2005
Doctoral Committee Chair(s)
Deborah Leckband
Department of Study
Chemical Engineering
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biophysics, General
Language
eng
Abstract
All three of the cadherins investigated in this thesis formed strong heterophilic bonds at three ectodomain alignments. Of the three, the inner bond (strongest) corresponding to full ectodomain overlap, did not exhibit much variation in either the homophilic or the heterophilic interactions. The two outer bonds (weaker) which are attributed to EC2/EC2 and EC1/EC1 binding, exhibit the greatest variation in bond strengths. In contrast to current thinking, these data show that there is no energetic preference for homophilic over heterophilic binding that would explain the cell sorting behavior.
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