Laminar Flow-Based Microchemical Systems for Power Generation, Electrochemical Synthesis, and Biological Cell Studies
Choban, Eric Raymond
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https://hdl.handle.net/2142/82369
Description
Title
Laminar Flow-Based Microchemical Systems for Power Generation, Electrochemical Synthesis, and Biological Cell Studies
Author(s)
Choban, Eric Raymond
Issue Date
2004
Doctoral Committee Chair(s)
Kenis, Paul J.A.
Department of Study
Chemical and Biomolecular Engineering
Discipline
Chemical and Biomolecular Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Chemical
Language
eng
Abstract
Similarly in this thesis, multistream laminar flow is used in microfluidic systems for (1) biocatalytic synthesis of fine chemicals by microscale-enabled efficient regeneration of cofactors, as well as for (2) the study of intestinal stem cells on a surface that mimics their in vivo environment. In the first system, the ability to focus reagent streams close to the electrode wall results in a cofactor regeneration efficiency of over 30%. In the second system, microfluidic networks are used to create covalently immobilized surface gradients of extracellular matrix (ECM) proteins, laminin and collagen 1. These microfluidic platforms are capable of eliciting cell responses such as migration, proliferation, and differentiation, and offer the possibility of in vitro studies of a variety cell lines in response to different immobilized and soluble ECM components.
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