Cognitive Differentiation of Schizophrenia and Depression
Keller, Jennifer
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https://hdl.handle.net/2142/82290
Description
Title
Cognitive Differentiation of Schizophrenia and Depression
Author(s)
Keller, Jennifer
Issue Date
1999
Doctoral Committee Chair(s)
Miller, Gregory A.
Department of Study
Psychology
Discipline
Psychology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Psychology, Clinical
Language
eng
Abstract
An ERP study of sensory and working memory was designed to avoid confounding MMN with other components. Schizophrenics, depressives, and controls performed a tone discrimination task, in which subjects counted or ignored tones. Evidence of memory abnormalities emerged as a function of diagnosis and stimulus sequence. All three groups showed intact auditory sensory memory, with comparable amplitudes and sequence effects. Schizophrenics did not differ from controls overall, but, in analyses as a function of diagnostic subtype, MMN was reduced in paranoid schizophrenics. Depressives showed dysfunctional working memory, as indexed by exaggerated N2b. Schizophrenics did not differ from controls overall, but, in analyses as a function of diagnostic subtype, N2b for was nonsignificantly higher in negative-symptom schizophrenics, who most resemble depressives. Results suggest that in certain MMN paradigms which removed stimulus confounds, schizophrenics can produce an normal MMN, which is appropriately influenced by preceding stimulus sequence. In addition, results suggest abnormal voluntary, strategy-sensitive processing in psychopathology, particularly in patients showing negative symptoms.
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