Acetylcholine Regulation of the Hippocampus and Striatum During Learning
Pych, Jason Clifford
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Permalink
https://hdl.handle.net/2142/82096
Description
Title
Acetylcholine Regulation of the Hippocampus and Striatum During Learning
Author(s)
Pych, Jason Clifford
Issue Date
2005
Doctoral Committee Chair(s)
Gold, Paul E.
Department of Study
Psychology
Discipline
Psychology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Neuroscience
Language
eng
Abstract
The present series of experiments evaluated the hypothesis that cholinergic activity regulates multiple memory systems. The hypotheses specifically tested were: (a) cholinergic activity in the hippocampus regulates place learning, (b) cholinergic activity in the striatum regulates response learning and (c) cholinergic activity in one structure regulates competitive interactions with the other. To this end, rats were tested in tasks in which acquisition of either place or response information led to the correct solution. In Chapter 2, rats were treated with intrastriatal glucose (glucose is hypothesized to upregulate cholinergic functioning) injections just prior to learning. In Chapters 3 and 4, acetylcholine release was measured in the hippocampus and striatum just prior to and during learning. The results, in general, support the hypothesis that increases in cholinergic activity in the hippocampus and striatum facilitate acquisition of place and response information, respectively, and that cholinergic activity in one structure can regulate competitive interactions with the other.
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