Photonic Crystal Enhanced-Fluorescence and Label -Free Bioimaging
Block, Ian D.
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Permalink
https://hdl.handle.net/2142/81136
Description
Title
Photonic Crystal Enhanced-Fluorescence and Label -Free Bioimaging
Author(s)
Block, Ian D.
Issue Date
2009
Doctoral Committee Chair(s)
Cunningham, Brian T.
Department of Study
Electrical and Computer Engineering
Discipline
Electrical and Computer Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Biomedical
Language
eng
Abstract
In further work, a theory is outlined for predicting photonic crystal label-free imaging resolution based on resonance spectral characteristics. Devices are characterized by patterning a resolution standard onto the sensor using photolithography, and excellent design control over label-free imaging resolution is demonstrated. The spectral response of a photonic crystal is optimized for improved label-free imaging of immobilized DNA microarray capture spots. Applications to protein microarrays and cell-based assays are also demonstrated.
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