A Computational-Experimental Study of Small Globular Proteins
Larios, Edgar
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Permalink
https://hdl.handle.net/2142/80512
Description
Title
A Computational-Experimental Study of Small Globular Proteins
Author(s)
Larios, Edgar
Issue Date
2005
Doctoral Committee Chair(s)
Martin Gruebele
Department of Study
Physics
Discipline
Physics
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biophysics, General
Language
eng
Abstract
The folding of small globular proteins is studied using a combination of experimental and computational techniques. The use of several experimental probes to study the formation of secondary and tertiary structure of proteins is stressed to obtain a description of their folding. Molecular dynamics simulations are carried out under non-physiological conditions to overcome experimental obstacles. Under physiological conditions, the combination of molecular dynamics and experiments resolves the folding of small proteins in great detail.
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