Influence of Thyroid Hormonal Status on Gene Expression for Calcium Channels in the Developing Olfactory Bulb and Cerebellum of the Postnatal Rat
Brown, Chester M.
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https://hdl.handle.net/2142/79975
Description
Title
Influence of Thyroid Hormonal Status on Gene Expression for Calcium Channels in the Developing Olfactory Bulb and Cerebellum of the Postnatal Rat
Author(s)
Brown, Chester M.
Issue Date
2007
Doctoral Committee Chair(s)
Esmail Meisami
Philip Best
Department of Study
Special Education
Discipline
Special Education
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
Based on our PCR results, it appears that the expression for these calcium channel genes is differentially regulated. In terms of development, the expression is tied more closely to development in the cerebellum than in the olfactory bulb. While expression appears to be regulated developmentally and by thyroid hormones, the effects are varied depending on both the tissue and channel. Taken together, this suggests that thyroid hormones due influence the expression of some calcium channels during postnatal development but the exact nature is unclear given the diversity of calcium channel expression in the mammalian brain.
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