Study of phenotypic and gene expression response to bacterial challenge

Nixon, Scott Evan

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https://hdl.handle.net/2142/78763 Copy

Description

Title

Study of phenotypic and gene expression response to bacterial challenge

Author(s)

Nixon, Scott Evan

Issue Date

2015-04-23

Director of Research (if dissertation) or Advisor (if thesis)

Rodriguez-Zas, Sandra L.

Doctoral Committee Chair(s)

Rodriguez-Zas, Sandra L.

Committee Member(s)

• Caetano-Anollés, Gustavo
• Chen, Xiaohui
• Kelley, Keith W.

Department of Study

Graduate College Programs

Discipline

Informatics

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

• Behavior
• Transcriptome
• Functional Analysis

Abstract

In the mouse model of Bacillus Calmette-Guérin (BCG)-induced inflammation, focus is placed upon phenotypic and gene-expression responses to the original challenge. Studies of the phenotypic response to BCG involves several behavior indicators, categorized as representing an initial period of sickness response, and a set of depression-like behaviors that can endure for several weeks. Little is known about the impact of relationships among indicators on these studies, as most analyses have treated indicators independently. Gene-expression studies have also been small in scale, limiting what is known about gene-expression during these behavioral changes. With the availability of Next-Generation Sequencing platforms, the scale of transcriptome analysis can be greatly increased. This study aims to address these previous limitations, characterizing behavioral and gene-expression responses to BCG-induced inflammation.

Graduation Semester

2015-5

Type of Resource

text

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http://hdl.handle.net/2142/78763

Copyright and License Information

Copyright 2015 Scott Nixon

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