Mueller-matrix-based analysis for second-harmonic generation imaging
Okoro, Chukwuemeka Onyekere
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https://hdl.handle.net/2142/78681
Description
Title
Mueller-matrix-based analysis for second-harmonic generation imaging
Author(s)
Okoro, Chukwuemeka Onyekere
Issue Date
2015-04-30
Department of Study
Electrical & Computer Eng
Discipline
Electrical & Computer Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Second-harmonic generation
Mueller matrix
Abstract
Second-harmonic generation microscopy takes advantage of second-order nonlinear property for imaging of biological structures. Invoking quantitative image analysis techniques facilitates the assessment of tissues in varying states.
This thesis presents a quantitative description of the relative structural difference in collagen-based tissues by second harmonic generation (SHG) imaging techniques involving polarization investigation. The Mueller matrix formalism demonstrates a polarization-based analysis approach for assessment of varying samples.
The associated second-order Mueller matrices are generated by applying
image processing algorithms to sub-grids of image sets obtained from a forward imaging microscope. By defining scalar metrics such as the degree of polarization and the depolarization, a quantitative evaluation of the samples under investigation is provided. A discussion of the capabilities for tissue assessment and techniques for improvements in the data acquisition speed and analysis will also be proffered
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