University of Illinois Urbana-Champaign

Elastomeric grating sensor for multifunctional optofluidic biosensing

Khan, Muhammad Ibrahim

Content Files
KHAN-THESIS-2015.pdf

Permalink

https://hdl.handle.net/2142/78607

Description

Title
Elastomeric grating sensor for multifunctional optofluidic biosensing
Author(s)
Khan, Muhammad Ibrahim
Issue Date
2015-04-13
Department of Study
Electrical & Computer Eng
Discipline
Electrical & Computer Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Date of Ingest
2015-07-22T22:33:15Z
Keyword(s)
  • Elastomeric grating sensor
  • Biofluid sensing
Abstract
Optical sensing techniques are being employed in widespread applications ranging from aerospace to electronics, process control and medicine. Optical biosensors are desirable in various clinical applications for their greater sensitivity, electrical passivity, wide dynamic range and high spatial resolution. Optical biosensors such as laser interferometers and optical fiber sensors can be incorporated for the real time measurement of biofluid parameters. Various applications in medicine such as blood monitoring in hemodialysis require the monitoring of multiple biofluid parameters. As multiple monitors are needed for sensing, the sensor becomes bulky and costly. Miniature optical sensors based on elastomers are best suited for this purpose. Sensors based on deformable elastomeric materials have several benefits such as greater sensitivity, high spatial resolution, reliability and low cost. The Multifunctional Elastomeric Grating Sensor (EGS) presented in this thesis is fabricated using elastomeric materials. The EGS is made by integrating a two-dimensional (2D) diffraction grating inside a hemispherical chamber. The sensing mechanism of the EGS is based on the diffraction of light. The laser beam passing through the 2D grating and the fluid inside the chamber is diffracted. The diffraction angle and the power of diffraction orders are used to compute the biofluid parameters. This sensor can be used for real time monitoring of glucose concentration, refractive index, pressure and opacity of the fluid. In future, the EGS will also be useful in highly sensitive temperature measurements. This device is being tested for more advanced biological experiments such as DNA hybridization and enzyme-linked immunosorbent assay (ELISA). This simple, compact and low cost device has an enormous potential for future use in various clinical applications such as blood monitoring in hemodialysis.
Graduation Semester
2015-5
Type of Resource
text
Permalink
http://hdl.handle.net/2142/78607
Copyright and License Information
Copyright 2015 Muhammad Ibrahim Khan

Owning Collections

Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois
Dissertations and Theses - Electrical and Computer Engineering
Dissertations and Theses in Electrical and Computer Engineering