Cell migration and alignment on mechanically controlled environment
Kwon, Gubeum
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https://hdl.handle.net/2142/78560
Description
Title
Cell migration and alignment on mechanically controlled environment
Author(s)
Kwon, Gubeum
Issue Date
2015-05-01
Department of Study
Mechanical Sci & Engineering
Discipline
Mechanical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
cell migration
cell alignment
contact guidance
cell-matrix interaction
Abstract
This thesis studies the effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration behavior on stiffness controlled three-dimensional in vitro environment. The continuous stiffness gradient 3D environment is provided by the effective stiffness on a PDMS wavy pattern, and the relationship between stiffness gradient and the cell migration is analyzed. Next, the effect of cell-cell interaction on cell alignment on a PDMS wavy pattern is studied. The previous study about the cell alignment behavior with feature characteristics is repeated for further research. Lastly, we look at the cell development behavior on various micro scale structures. Tubule etching structures, ribbon-like 3D structures, and table structures are explored to observe the cell growth, migration, alignment, and even the effect of cells on those structures. Studying the mechanically controlled environment on cells would provide easier and more precise controllable methods for tissues engineering and regenerative medicine.
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