University of Illinois Urbana-Champaign

The Influence of Pressure on The Low-Temperature Kinetics of Myoglobin

Sorensen, Larry Brice

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https://hdl.handle.net/2142/77188

Description

Title
The Influence of Pressure on The Low-Temperature Kinetics of Myoglobin
Author(s)
Sorensen, Larry Brice
Issue Date
1980
Department of Study
Physics
Discipline
Physics
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Physics, Molecular
Language
eng
Abstract
  • The recombination of carbon monoxide and dioxygen to horse and sperm whale myoglobin at low temperatures (60 - 160K) was studied using high pressure flash photolysis techniques. By comparing the pressure dependence when the system is first frozen and then pressurized with the pressure dependence when the system is first pressurized and then frozen, the total volume change for the reaction can be resolved into an activation volume component and a conformational volume component. Strong evidence requiring both conformational volume and activation volume components was found. Over the pressure range studied (0.1 - 200 MPa) the observed volume changes were independent of the applied pressure.
  • At low temperatures, the recombination reaction must be described by a distribution of activation enthalpies. A simple configuration coordinate model was developed which predicts distributions in excellent agreement with the observed distributions.
Graduation Semester
1980
Type of Resource
text
Permalink
http://hdl.handle.net/2142/77188

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