A Plethora of T cells Activated by Drug-Encapsulated Liposomes in a Tumor-Draining Lymph Node of a Mouse

Landsman, Rebekah

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https://hdl.handle.net/2142/75925 Copy

Description

Title

A Plethora of T cells Activated by Drug-Encapsulated Liposomes in a Tumor-Draining Lymph Node of a Mouse

Author(s)

Landsman, Rebekah

Contributor(s)

Roy, Edward

Issue Date

2015-04

Keyword(s)

• Immunotherapy
• Molecular and Cellular Biology

Abstract

This is an image of a very thin section of a tumor-draining lymph node of a mouse. It is stained for nuclei of cells (the blue stain) and for specific T cells (the red stain). The lab that I work in seeks to understand how to best manipulate the immune system to fight cancer. In my research, I directly injected drug-encapsulated liposomes, made for us by Cartney Smith of Dr. Kongs lab, into the tumor draining lymph node of a mouse. The liposomes contain an activating agent, a steroid to counter suppression, and a peptide specific for the T cells seen in the picture. The liposomes successfully induced the proliferation of T cells, a cell type important to fight cancer. By injecting directly into the lymph node we were able to see a much larger number of T cells, as seen in this picture, compared to mice that did not receive any liposomes. For more information about the Image of Research--Undergraduate Edition go to: http://go.library.illinois.edu/imageofresearch_uredition

Type of Resource

• text
• image

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http://hdl.handle.net/2142/75925

Copyright and License Information

Copyright 2015 Rebekah Landsman

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