A histological view of pre-natal exposure to bisphenol A in the rat ovary

Sczygelski, Mallory

Permalink

https://hdl.handle.net/2142/75870 Copy

Description

Title

A histological view of pre-natal exposure to bisphenol A in the rat ovary

Author(s)

Sczygelski, Mallory

Contributor(s)

The Members of the Flaws Laboratory

Issue Date

2015-04

Keyword(s)

• Comparative Biosciences
• Veterinary Medicines

Abstract

This is a picture of a rat ovary treated with Bisphenol A (BPA) on post-natal day 21. BPA is a chemical found in polycarbonate plastics and epoxy resins commonly used in the linings of beverage and food product containers. BPA can be released from these products and consumed by humans and animals. Previous studies have shown BPA exposure during adult life inhibits follicle growth in the rodent ovary. However, little is known about the effects of in utero BPA exposure on the ovaries of the offspring (F1 generation). This study was designed to test the hypothesis that pre-natal exposure to BPA decreases expression of key regulators of ovarian function in the offspring by gene expression analysis and histological evaluation. This study also examined the response of the ovary to BPA when dams are on a high-fat diet because pregnant females are often simultaneously exposed to BPA and a high-fat diet.

Type of Resource

• text
• image

Permalink

http://hdl.handle.net/2142/75870

Copyright and License Information

Copyright 2015 Mallory Sczygelski

Owning Collections