Interfacing Nanomaterials With Fluids and Living Biological Systems
Yum, Kyungsuk
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Permalink
https://hdl.handle.net/2142/72230
Description
Title
Interfacing Nanomaterials With Fluids and Living Biological Systems
Author(s)
Yum, Kyungsuk
Issue Date
2009
Doctoral Committee Chair(s)
Yu, Min-Feng
Department of Study
Mechancial Engineering
Discipline
Mechanical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Biomedical
Engineering, Mechanical
Engineering, Materials Science
Abstract
Advances in nanotechnology are generating new knowledge and technology that impact many scientific and technological areas. Nanomaterials have played an important role in the advances: they have served as model systems to explore nanoscale physics and as building blocks to develop nanoscale tools and devices. The rational applications of nanomaterials require understanding of their fundamental properties. Early studies of nanomaterials---characterization of individual nanomaterials (e.g., carbon nanotubes)---have mostly focused on their basic mechanical and electrical properties. Most of these studies have relied on tools and methods rooted in solid-state physics, such as electron microscopes, scanning probe microscopes, and microfabricated testing devices; thus, the tools and methods were difficult to incorporate "soft" materials, rooted in chemistry and biology, into the studies. Despite enormous potential of technologies that integrate nanomaterials (more generally, nanotechnology and the physical sciences) and "soft" materials (more generally, chemical and biological systems), the basic knowledge of how "hard" nanomaterials interact with "soft" materials and how to interface "inorganic" nanomaterials with "organic" biomolecules and living biological systems was lacking.
In this dissertation, we studied the interfaces and interactions of "hard" nanomaterials and "soft" materials, from fluids to living biological cells, at the nanoscale and presented a new concept to interface nanomaterials with living biological systems for biological and biophysical studies inside living cells at the nanoscale. In the first part, we present the study of how fluids interact with nanomaterials and how fluids behave at very small length scales, using nanotubes as model systems. In the second part, we present the development of nanotechnology-based tools for single cell studies at the nanoscale: single nanotube-based needle nanoprobes for biological and chemical sensing and high-precision nanoscale delivery methods for biological and biophysical studies inside living cells.
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