Dynamics and Structures of Phospholipid Assemblies
Yan, Yu
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https://hdl.handle.net/2142/72167
Description
Title
Dynamics and Structures of Phospholipid Assemblies
Author(s)
Yan, Yu
Issue Date
2009
Doctoral Committee Chair(s)
Granick, Steve
Department of Study
Materials Science and Engineering
Discipline
Materials Science and Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Physical
Biophysics, General
Engineering, Materials Science
Abstract
This thesis studies structures and dynamics of phospholipids vesicles and their interactions with nanoparticles and peptides, with a focus on the following problems: (1) Single-vesicle dynamics for new colloidal physics. Phospholipids vesicles are stabilized by physically adsorbed nanoparticles, and employed as a unique system, in which the vesicles in dense suspensions exhibits dynamical features corresponding to their soft, hollow and polydisperse characteristics. (2) Shape transformation of lipid membrane. Seeking a general understanding of shape deformations associated with biological functions and cell proliferation, morphologies of giant lipid vesicles are studied to reveal their interactions with nanoparticles and pore-forming peptides. Nanoparticle-induced pearling and peptide-induced raft budding of giant lipid vesicles provide facile strategies to reproduce cellular shape transformations in vitro . These studies bridge the cell biology with materials, chemistry and physics.
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