Metabolism of Two Model Xenobiotics in Cultured Plant Cells
Blair, Louis Curtis
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https://hdl.handle.net/2142/71582
Description
Title
Metabolism of Two Model Xenobiotics in Cultured Plant Cells
Author(s)
Blair, Louis Curtis
Issue Date
1983
Department of Study
Agronomy
Discipline
Agronomy
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Plant Physiology
Abstract
Plant cells in culture were found to oxygenate two model xenobiotics. Para-chlorophenyl methyl sulfide was S-oxidized by carrot, cotton, tobacco, alfalfa, and blacknightshade cell cultures. The rates of S-oxygenation by cultured plant cells were comparable to the rates in animal tissue preparations. The plant cell metabolism of the promutagen-procarcinogen 2-aminofluorene was evaluated by a mutagen bioassay. The mutagenic activation of 2-aminofluorene by cultured plant cells was detected by the induction of reverse mutation at the his locus of Salmonella typhumerium. A photoautotrophic cotton cell culture was developed to facilitate xenobiotic metabolism research in photosynthetic cultured plant cells.
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