Systemic and Regional Distribution of Blood Flow During T-2 Toxin Induced Shock in Swine (Microspheres)
Lundeen, Gregg Richard
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https://hdl.handle.net/2142/71343
Description
Title
Systemic and Regional Distribution of Blood Flow During T-2 Toxin Induced Shock in Swine (Microspheres)
Author(s)
Lundeen, Gregg Richard
Issue Date
1987
Department of Study
Veterinary Medical Science
Discipline
Veterinary Medical Science
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Veterinary Science
Abstract
Three groups of swine (6 per group) were used to assess alterations in blood flow induced by single doses of T-2 toxin infused into the pulmonary artery. Two groups were dosed at 0.6 or 2.4 mg/kg T-2 toxin and the third group served as a vehicle control (70% ethanol). Organ blood flow was determined at 0 hour (predosing) and at 90 minute intervals for 6 hours, using the radiolabeled microsphere technique. Hemodynamic parameters were obtained at the same time points.
The infusion of T-2 toxin resulted in reductions in cardiac output (CO). This trend appeared to reverse itself in the low dose group after 3 hours, whereas in the high dose group, CO continued to decline. Alterations in mean arterial pressure (MAP) paralleled the reduction observed in CO. A compensatory tachycardia was observed in response to the reduced CO and MAP.
Renal, pancreatic and splenic blood flows were the most severely compromised by T-2. Blood flow to the brain and heart also decreased but to a lesser degree. In contrast, adrenal, hepatic and gastrointestinal blood flow increased following toxin administration.
The effects of T-2 toxin on systemic and regional blood flow have not been previously described. It was the goal of this study to characterize the functional alterations comprising this shock syndrome with regard to blood flow. These findings indicate that T-2 toxicosis involves a complex interaction of multiple organ systems. The animals observed in this study exhibited classic signs of circulatory shock which included hypotension, tissue hypoperfusion and reduced cardiac output. The alterations in organ/tissue blood flow observed in this study may help previously reported effects of T-2 toxin on various physiologic and pathologic parameters.
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