Toxicity and Teratogenicity of Conium Maculatum in Swine and Hamsters
Panter, Kip Eugene
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https://hdl.handle.net/2142/71302
Description
Title
Toxicity and Teratogenicity of Conium Maculatum in Swine and Hamsters
Author(s)
Panter, Kip Eugene
Issue Date
1983
Department of Study
Veterinary Medical Science
Discipline
Veterinary Medical Science
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Veterinary Science
Abstract
Feeding trials presented in this research thesis positively show that poison hemlock seed and plant material are both toxic and teratogenic in swine.
Clinical signs of poison hemlock toxicosis in swine included partial to complete covering of the eyes by the 3rd eyelids progressing to temporary blindness about 15 minutes after feeding followed by ataxia, trembling, and muscular weakness. Other clinical signs were frequent urination and defecation, slight dilation of the pupils, initial strong rapid heart beats that later became slowed and shallow. Early in the syndrome, respirations were rapid and shallow but later became slowed and deep. Death occurred without convulsions about 1 hour after feeding an estimated daily dose of 1.5 gm/kg of Utah seed or 8.5 gm/kg of Utah spring growth plant.
Five types of hemlock plant material were fed to pregnant gilts for teratogenicity studies. Illinois fall growth, Illinois spring growth, Illinois seed, Utah seed, and Utah spring growth. All were teratogenic in swine except for the Illinois spring growth plant material.
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