Absorption, Distribution and Excretion of Oxytetracycline and Tetracycline in Female Beagles
Bass, Vivian Dee
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https://hdl.handle.net/2142/71301
Description
Title
Absorption, Distribution and Excretion of Oxytetracycline and Tetracycline in Female Beagles
Author(s)
Bass, Vivian Dee
Issue Date
1983
Department of Study
Veterinary Medical Science
Discipline
Veterinary Medical Science
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Pharmacology
Abstract
The absorption, distribution and excretion of oxytetracycline and tetracycline were studied in female beagles following intra-arterial and oral drug administration. Concentrations of drug in body fluids and selected tissues were determined by high performance liquid chromatography utilizing an internal standard. The average biologic half-life of oxytetracycline was 6.4 hours, whereas that of tetracycline was 13.7 hours following intra-arterial administration (10 mg/kg body weight). The half-life of tetracycline was decreased to 8.2 hours when a lower dose (5 mg/kg body weight) was administered. Oxytetracycline and tetracycline were rapidly but incompletely absorbed when administered to canines per os. Both antibiotics had similar absorption (< 0.5 hr) and elimination (4.8-6.6 hrs) half-lives. Comparisons of the recovery of both drugs in urine following intra-arterial and oral drug administration revealed that tetracycline had a higher bioavailability (35.9%) than that determined for oxytetracycline (10.7%). Following intra-arterial administration of oxytetracycline (10 mg/kg body weight) the highest concentration of drug was present in the kidney, followed by the liver, heart, muscle, and lung in declining order of concentration. A positive correlation was demonstrated between coexistent mean plasma and tissue concentrations for the tissues examined.
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