Antiviral, Cytotoxic and Antimicrobial Compounds From Marine Sponges and Algae (Biological Activity)
Koker, Moustapha Edward Sesse
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https://hdl.handle.net/2142/70337
Description
Title
Antiviral, Cytotoxic and Antimicrobial Compounds From Marine Sponges and Algae (Biological Activity)
Author(s)
Koker, Moustapha Edward Sesse
Issue Date
1985
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Organic
Abstract
The antiviral and antimicrobial compounds sceptrin, oxysceptrin, bromosceptrin, debromosceptrin, dibromosceptrin and debromooxysceptrin have been isolated from the sponge Agelas mauritiana and their structures have been determined by spectroscopic means. Syntheses of model compounds for some of the structures assigned were also carried out.
An investigation of biologically active compounds from Dictyopteris undulata has led to the isolation of zonarol, chromazonarol, zonaroic acid and isozonaroic acid and structure determination by chemical transformation and spectroscopic means. All of these compounds exhibited antimicrobial activity and some also showed activity against LI210 cells and antiviral activity.
A study of Pseudoceratina crassa has yielded (+)-aeroplysinin-1 as the bioactive principle. This compound exhibited antimicrobial activity and activity against LI210 and P388 leukemia cells.
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