Two-Dimensional Electrode Array Studies of Propagating Epileptiform Neural Activity in the Rat Hippocampal Slice
Novak, James Lawrence
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https://hdl.handle.net/2142/69401
Description
Title
Two-Dimensional Electrode Array Studies of Propagating Epileptiform Neural Activity in the Rat Hippocampal Slice
Author(s)
Novak, James Lawrence
Issue Date
1988
Department of Study
Electrical Engineering
Discipline
Electrical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Neuroscience
Engineering, Biomedical
Engineering, Electronics and Electrical
Abstract
A technique has been developed in which a planar array of 32 microelectrodes, arranged in a 4 by 8 pattern with 200 $\mu$m separation, is used to record from and to stimulate the rat hippocampal slice preparation at multiple sites. Active suppression circuitry is used to prevent device saturation due to large stimulation artifacts. Control of media flow past the tissue is critical to observe signals and to preserve viability. The field potentials recorded are spatially unique and provide a two-dimensional description of the underlying population activity in the various pyramidal cell strata and subpopulations. The application of current source density analysis to the potential data permits accurate determination of peak times, in addition to the estimation of local current sources and sinks. Propagation delays of the compound action potential, first, and second population spikes along CAl calculated using these peak times are not uniform, and may indicate differences and directionality in coupling mechanisms.
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