Biological Potencies and Mechanism of Action of Estrogens and Antiestrogens in Primary Cell Cultures of Human Endometrium and in Mcf-7 Human Breast Carcinoma Cells in Vitro
Eckert, Richard Leon
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https://hdl.handle.net/2142/68309
Description
Title
Biological Potencies and Mechanism of Action of Estrogens and Antiestrogens in Primary Cell Cultures of Human Endometrium and in Mcf-7 Human Breast Carcinoma Cells in Vitro
Author(s)
Eckert, Richard Leon
Issue Date
1981
Department of Study
Physiology and Biophysics
Discipline
Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Language
eng
Abstract
Primary cultures of human endometrial cells were used to examine the direct effects of estrogens on progesterone receptor levels in vitro. Cells, grown in Dulbecco's EMEM, showed maximal stimulation of progesterone receptor (PR, 7-fold) after a 3-4 d incubation with 10nM estradiol (E(,2)). The
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