Amino Acid Limitation Induces the Amino Acid Response (AAR) Pathway in a Time-and Species-Specific Manner
Anderson, Heather; Wang, Huan; Li, Qian; Pan, Yuan-Xiang; Chen, Hong
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https://hdl.handle.net/2142/66348
Description
Title
Amino Acid Limitation Induces the Amino Acid Response (AAR) Pathway in a Time-and Species-Specific Manner
Author(s)
Anderson, Heather
Wang, Huan
Li, Qian
Pan, Yuan-Xiang
Chen, Hong
Issue Date
2014
Keyword(s)
amino acid limitation
AAR
human
rat
hepatoma
HepG2
Abstract
Amino acids are critical to life and play central roles both as building blocks of proteins and as intermediates in metabolism. The amino acid response (AAR) pathway is activated by lacking of amino acids (i.e. amino acid starvation). We hypothesized that the activation of AAR pathway might occur in a time-dependent manner in hepatoma cells, which might induce restriction of protein production from DNA. Real-time RT-PCR was used to investigate mRNA expressions during this process. Our results showed that expression of Atf3, Chop, and Asns genes were induced significantly by amino acid deprivation in a time- and species- dependent manner.
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