Magnetic resonance spectroscopy: techniques and applications in thermometry and metabolite mapping

Wilder, Hailey

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https://hdl.handle.net/2142/50635 Copy

Description

Title

Magnetic resonance spectroscopy: techniques and applications in thermometry and metabolite mapping

Author(s)

Wilder, Hailey

Issue Date

2014-09-16

Director of Research (if dissertation) or Advisor (if thesis)

Sutton, Bradley P.

Department of Study

Bioengineering

Discipline

Bioengineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• Magnetic Resonance Spectroscopy Imaging (MRSI)
• Single Voxel Spectroscopy (SVS)
• Thermometry
• 2d 3d chemical shift image (CSI)
• Multi-Dimensional Chemical Shift Imaging (CSI)
• Segmentation and Metabolite Mapping

Abstract

Magnetic Resonance Spectroscopy (MRS) is a useful tool for obtaining information about metabolite concentrations. Information that can be extrapolated from these concentrations may be absolute or relative in nature, depending on the availability of an internal reference. For example, MR Thermometry using Single Voxel Spectroscopy (SVS) utilizes the water peak as an internal reference to observed metabolites offering a means of interpreting absolute metabolite values. On the other hand, metabolite mapping is best performed by utilizing water suppression since the water peak is of a magnitude 10^4 times larger than metabolite peaks. In this case metabolite information is characterized relative to other metabolites and a metabolite of interest is given as a percentage. Sensitivity in MRS is of the utmost concern since metabolites appear at such small concentration in the brain. Thus, metabolite peak position using a Guassian and Hamming filters and the adaptation of chemical shift imaging from 2D to 3D is useful in obtaining more precise information. Herein, it is shown that both absolute and relative quanti cation can be improved through, respectively, frequency filters and increased dimensional acquisition.

Graduation Semester

2014-08

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http://hdl.handle.net/2142/50635

Copyright and License Information

Copyright 2014 Hailey Wilder

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