Withdraw
Loading…
MANET and the evolution, structure and function of biological networks
Mughal, Fizza
Content Files

Loading…
Download Files
Loading…
Download Counts (All Files)
Loading…
Edit File
Loading…
Permalink
https://hdl.handle.net/2142/50497
Description
- Title
- MANET and the evolution, structure and function of biological networks
- Author(s)
- Mughal, Fizza
- Issue Date
- 2014-09-16
- Director of Research (if dissertation) or Advisor (if thesis)
- Caetano-Anolles, Gustavo
- Department of Study
- Crop Sciences
- Discipline
- Bioinformatics
- Degree Granting Institution
- University of Illinois at Urbana-Champaign
- Degree Name
- M.S.
- Degree Level
- Thesis
- Date of Ingest
- 2014-09-16T17:18:02Z
- Keyword(s)
- Metabolic Networks
- Enzyme Evolution
- Phylogenomics
- Protein Domain
- Abstract
- The metabolic MANET is an online resource that incorporates data from KEGG, SCOP and structural phylogenomics. A revised version of MANET was here produced that not only uses recent data from KEGG and SCOP, but also evolutionary information of fold families derived from structural phylogenomic reconstructions. In addition, a fourth data source, PDBsum, has been added to this resource amalgamation, which serves to provide the link between enzyme and PDB information. With the introduction of fold family data, the updated version offers a 10-fold increase of data entries compared to the current version that is based on fold data. The global analysis of metabolism at mesonetwork as well as the subnetwork level puts forth interesting patterns of enzyme sharing that lend support to the patchwork model of metabolic evolution. The sharing patterns we identify are not just restricted to subnetworks. Instead, they transcend mesonetwork boundaries.
- Graduation Semester
- 2014-08
- Permalink
- http://hdl.handle.net/2142/50497
- Copyright and License Information
- Copyright 2014 Fizza Mughal
Owning Collections
Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at IllinoisManage Files
Loading…
Edit Collection Membership
Loading…
Edit Metadata
Loading…
Edit Properties
Loading…
Embargoes
Loading…