Engineering mesoporous silicon for cell biology applications
Huang, Tiffany
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https://hdl.handle.net/2142/50464
Description
Title
Engineering mesoporous silicon for cell biology applications
Author(s)
Huang, Tiffany
Issue Date
2014-09-16
Director of Research (if dissertation) or Advisor (if thesis)
Kilian, Kristopher A.
Department of Study
Materials Science & Engineerng
Discipline
Materials Science & Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Porous Silicon
Bioconjugation
Stem cells
Optical sensors
Surface chemistry
Abstract
Porous Silicon is a material that is made when an electric potential is applied to silicon using a hydrofluoric acid electrolyte. The structure of porous silicon is of interest for cell biological applications due to the large surface area and optical properties. To render the material biocompatible we modify porous silicon using hydrosilylation and bioconjugation techniques to render it inert to degradation and allow for cell adhesion. We looked at the potential to use porous silicon as a co-culture by patterning it with patterned regions of different adhesive peptides using a novel lithography method with gold. Next we exploited the high surface area of the material to incorporate small molecules in the structure. Then we used it for cell culture, so that drug releases directly into the cells. We then explored the optical properties of porous silicon to create a stimuli responsive sensor using a composite with a PEG hydrogel. Finally we looked at the potential of topographically modified porous silicon to be used for cell culture
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