"""Bend it"": Membrane sculpting by F-BAR domain lattices"

Yu, Hang

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https://hdl.handle.net/2142/49201 Copy

Description

Title

"""Bend it"": Membrane sculpting by F-BAR domain lattices"

Author(s)

Yu, Hang

Contributor(s)

Svinarski, Olga, and Schulten, Klaus

Issue Date

2014-05

Keyword(s)

Biophysics and Computational Biology

Abstract

The image shows how a particular protein, named F-BAR domain, works in teams to bend flat cellular membrane into tubules. To generate organelles, eukaryotic cells sculpt their membranes into compartments, often employing proteins as chaperones,for example, F-BAR domains. The latter induce formation of tubular and vesicular membranes. To generate large membrane curvatures, cells arrange F-BAR domain proteins in lattices on the surface of cellular membranes. F-BAR domain lattices collectively generate large membrane curvatures and play important function in sculpting cellular compartments. The membrane sculpting process has been simulated with molecular dynamics simulations on super computers with NAMD and VMD.

Type of Resource

• text
• image

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http://hdl.handle.net/2142/49201

Copyright and License Information

Copyright 2014 Hang Yu

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