University of Illinois Urbana-Champaign

Optofluidic Sensor for Sensing Fluid Properties and Protein Binding

Li, Shuo

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https://hdl.handle.net/2142/47612

Description

Title
Optofluidic Sensor for Sensing Fluid Properties and Protein Binding
Author(s)
Li, Shuo
Contributor(s)
Liu, Gang Logan
Issue Date
2013-05
Keyword(s)
  • optofluidic sensor
  • elastomeric 2D grating
  • dialysis monitoring
Abstract
We aimed to present an optofluidic sensor based on integrating a flexible two-dimensional (2D) grating with nanopyramid arrays and a half-dome fluid chamber made by Polydimethylsiloxane (PDMS). The motivation and purpose of our project is to develop a low-cost fluid monitor which has potential applications in medical treatments. In our experiment, the laser beam is diffracted before (reflection) and after (transmission) going through the grating and liquid in the fluid chamber. By analyzing the size, power and shape of the 2D diffraction patterns, we can retrieve multiple parameters of the liquid including the refractive index, pressure, and opacity with high sensitivity. The free-solution binding of bovine serum albumin (BSA) and anti-BSA IgG can also be detected with this sensor prototype. This low-cost, multi-functional, and reliable optofluidic sensor has the potential to be used as a monitor for biofluids such as a blood monitor in hemodialysis.
Type of Resource
text
Language
en
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http://hdl.handle.net/2142/47612

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