University of Illinois Urbana-Champaign

Modeling the Angular Light Scattering by Red Blood Cells

Lim, Joonoh

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https://hdl.handle.net/2142/46953

Description

Title
Modeling the Angular Light Scattering by Red Blood Cells
Author(s)
Lim, Joonoh
Contributor(s)
Popescu, Gabriel
Issue Date
2011-05
Keyword(s)
  • red blood cells
  • angular light scattering
  • modeling
  • blood screening
  • label-free blood testing
Abstract
The primary role of the red blood cell is delivering oxygen throughout the body. If it is affected, consequences include amnesia and numerous diseases such as malaria and sickle cell anemia. As prompt and inexpensive tests for blood screening are in demand, we have developed a faster and reliable way to measure parameters associated with the structure of red blood cells and size distribution of the cells in whole blood smear. Using the Born approximation and simulating red blood cell shape, we were able to determine the diameter, thickness, and other parameters related to the cell morphology. Given a phase image of red blood cell smear measured in our laboratory, we can determine the average and standard deviation of the diameter of red blood cells simultaneously, without analyzing cell by cell individually. This approach may open the door for a new generation of label-free testing.
Type of Resource
text
Language
en
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http://hdl.handle.net/2142/46953

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