Worm-shaped polymersomes and their effects on targeting efficiency

Choi, Je

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https://hdl.handle.net/2142/46914 Copy

Description

Title

Worm-shaped polymersomes and their effects on targeting efficiency

Author(s)

Choi, Je

Issue Date

2014-01-16T18:26:11Z

Director of Research (if dissertation) or Advisor (if thesis)

Kong, Hyun Joon

Department of Study

Chemical & Biomolecular Engr

Discipline

Chemical Engineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

particle shape

Abstract

In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability than spherical polymersomes. Morphology of the resulting polymersome was observed afterwards. The polymersome was further modified to present Arg-Gly-Asp (RGD) motif, which is known to bind with cells that overexpress integrins. The binding affinities of the polymersomes onto target substrates were assessed using surface plasmon resonance (SPR) spectroscopy and adherence of the polymersomes to a target cell layer was also evaluated using flow chamber simulating blood flow.

Graduation Semester

2013-12

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http://hdl.handle.net/2142/46914

Copyright and License Information

Copyright 2013 Je Choi

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