High-speed polarization-sensitive optical coherence tomography: toward intraoperative cancer imaging

South, Fredrick A.

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Description

Title

High-speed polarization-sensitive optical coherence tomography: toward intraoperative cancer imaging

Author(s)

South, Fredrick A.

Issue Date

2014-01-16T17:54:50Z

Director of Research (if dissertation) or Advisor (if thesis)

Boppart, Stephen A.

Department of Study

Electrical & Computer Eng

Discipline

Electrical & Computer Engr

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• biomedical imaging
• optical coherence tomography
• breast cancer
• polarization

Abstract

Successful treatment of most breast cancers requires surgical removal of the tumor. The current standard-of-care does not provide any tools for real-time assessment of the tumor cavity. Optical coherence tomography (OCT) has previously been developed for real-time intraoperative use in hopes of aiding tumor margin assessment. While there has been much success, it remains difficult to distinguish between normal stroma tissue and breast cancer. Polarization-sensitive optical coherence tomography (PS-OCT) is an extension of OCT that measures both the intensity and polarization of light returning from the tissue. PS-OCT is sensitive to changes in collagen structure and may provide additional contrast between normal and diseased tissue. This thesis reports the development of a real-time PS-OCT system using a high-speed swept-source laser and parallel processing on a graphics processing unit (GPU). Results of a preliminary imaging study are also reported, demonstrating that PS-OCT provides enhanced contrast between previously indistinguishable fibrous stroma and invasive ductal carcinoma (IDC).

Graduation Semester

2013-12

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http://hdl.handle.net/2142/46580

Copyright and License Information

Copyright 2013 Fredrick South

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