Prostate tissue diagnosis using quantitative phase imaging techniques
Sridharan, Shamira
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https://hdl.handle.net/2142/45541
Description
Title
Prostate tissue diagnosis using quantitative phase imaging techniques
Author(s)
Sridharan, Shamira
Issue Date
2013-08-22T16:47:10Z
Director of Research (if dissertation) or Advisor (if thesis)
Popescu, Gabriel
Department of Study
Bioengineering
Discipline
Bioengineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
prostate
cancer
quantitative phase imaging (QPI)
spatial light interference microscopy (SLIM)
Gleason grading
nucleus
Abstract
The lifetime risk of a man getting diagnosed with prostate cancer is 1 in 6. The diagnosis is made by the pathologist using staining methods and immunohistochemical markers to detect malignancy on tissue biopsy sections. Quantitative phase imaging methods eliminate the need for stains and markers. It exploits the intrinsic contrast from the refractive index differences in tissue. The quantitative nature of this technique eliminates inter-observer variability. QPI is sensitive to sub-nanometer level changes in tissue architecture. Light scattering information is also accessible from QPI images since it records both the amplitude and the phase of light that passes through the sample. In this thesis, I show the ability of QPI to distinguish between cancerous and benign samples. I also show its ability to detect changes in stroma and nuclei through different stages of prostate cancer progression that are not detectable using conventional methods.
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