Graphene supported hafnium oxide nanopores for DNA sensing

Rivera, Jose

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https://hdl.handle.net/2142/44455 Copy

Description

Title

Graphene supported hafnium oxide nanopores for DNA sensing

Author(s)

Rivera, Jose

Issue Date

2013-05-24T22:16:42Z

Director of Research (if dissertation) or Advisor (if thesis)

Bashir, Rashid

Department of Study

Bioengineering

Discipline

Bioengineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• nanopores
• DNA sensing
• graphene
• solid-state nanopores
• graphene membrane
• transmission electron microscopy (TEM)

Abstract

The completion of the Human Genome Project in 2001 has served as both an inspiration and a challenge for researchers in the past decade. Understanding the genetic makeup of organisms is crucial for early disease detection, one of the driving forces behind personalized medicine. In this work, state-of-the-art sequencing technologies are reviewed and compared with next-generation sequencing technologies. In particular, solid-state nanopores are investigated and recent developments in the field are discussed. The interdisciplinary effort from researchers to establish solid-state nanopores as a viable sequencing platform is thriving on multiple fronts including surface charge engineering for DNA capture and conductance modulation in nanopores, nanowire transistors for localized detection, ultra-thin membrane fabrication using graphene, and the exploration of alternative nanopore materials for biosensing applications. In this work, the development of a new solid-state nanopore sensor consisting of hafnium oxide suspended by functionalized graphene is reported along with DNA transport properties and dielectric characterization of the film in solution.

Graduation Semester

2013-05

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http://hdl.handle.net/2142/44455

Copyright and License Information

Copyright 2013 Jose Rivera

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