Synthesis and characterization of nanoparticle suspensions: Towards quantitative surface-enhanced Raman spectroscopic sensing
Devetter, Brent M.
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https://hdl.handle.net/2142/44419
Description
Title
Synthesis and characterization of nanoparticle suspensions: Towards quantitative surface-enhanced Raman spectroscopic sensing
Author(s)
Devetter, Brent M.
Issue Date
2013-05-24T22:15:26Z
Director of Research (if dissertation) or Advisor (if thesis)
Bhargava, Rohit
Department of Study
Electrical & Computer Eng
Discipline
Electrical & Computer Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
surface-enhanced Raman spectroscopy
gold nanoparticles
plasmonics
chemical sensing
Abstract
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive technique with applications
ranging from in vitro and in vivo biological sensing to chemical and explosives detection. In this
thesis, we explore the design and characterization of suspensions of nanoparticles prior to their
use for SERS-based molecular sensing. A major problem in SERS-based measurements is that
the signals are often not interpreted quantitatively. Measurements performed in suspension
mimic the nanoprobe-to-nanoprobe optical interactions expected to be found in tissues with
embedded nanoprobes while particle-level measurements of synthesized nanoparticles provide
the molecular basis for calculations. We find that careful consideration of the localized surface
plasmon resonance of SERS nanoprobes with respect to laser excitation wavelength is essential
for maximizing detectable SERS signal. Additionally, the reporter molecule load per particle
depends on synthesis conditions and the shape of the nanoparticles. Together, well-characterized
suspensions can be used to understand the molecular and electromagnetic aspects of recorded
SERS data.
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