Studies towards understanding the function of LanCL1
Koh, Tong Hee
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https://hdl.handle.net/2142/31101
Description
Title
Studies towards understanding the function of LanCL1
Author(s)
Koh, Tong Hee
Issue Date
2012-05-22T00:27:55Z
Director of Research (if dissertation) or Advisor (if thesis)
van der Donk, Wilfred A.
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
LanCL1
protein-protein interaction
apoptosis
oxidative stress
knockout mouse
Abstract
LanC-like protein 1 (LanCL1) is a eukaryotic homolog of bacterial protein LanC. Unlike the well studied LanC proteins, the functions of LanC-like proteins are yet unknown. To investigate the function of LanCL1 several studies were undertaken. Proteins interacting LanCL1 were tried to be found but were not accomplished. Also, the role of LanCL1 in apoptosis and oxidative stress were hypothesized, but the studies indicated no correlation. Finally, LanCL1 knockout mice were generated for further investigation.
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