Physical models of protein folding within the energy landscape theory
Plotkin, Steven S.
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https://hdl.handle.net/2142/30847
Description
Title
Physical models of protein folding within the energy landscape theory
Author(s)
Plotkin, Steven S.
Issue Date
1998
Doctoral Committee Chair(s)
Wolynes, P.G.
Department of Study
Physics
Discipline
Physics
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
protein folding
energy landscape theory
potential energy surface
partially random heteropolymer
Language
en
Abstract
The energy landscape theory of protein fol9.ing is based on a statistical description of
a protein's complex potential energy surface. Individual folding events are sampled
from an ensemble of possible routes on the landscape. The theory suggests that the
landscape of a protein can be described as that of a partially random heteropolymer
with a rugged, yet funnelled landscape towards the native structure. The quantitative
aspects of folding are developed using tools from the statistical mechanics of disordered
systems, polymers, and phase transitions of finite systems. The theory provides an
interpretation of results from fast folding experiments as well as minimalist models
used in computer simulations.
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