University of Illinois Urbana-Champaign

Domain-based approaches to understanding phylogeny and orthology

Ger, Mao-Feng

Content Files
Mao-Feng_Ger.pdf

Permalink

https://hdl.handle.net/2142/29798

Description

Title
Domain-based approaches to understanding phylogeny and orthology
Author(s)
Ger, Mao-Feng
Issue Date
2012-02-06T20:17:43Z
Director of Research (if dissertation) or Advisor (if thesis)
Jakobsson, Eric
Committee Member(s)
  • Grosman, Claudio F.
  • Zhong, Sheng
  • Ma, Jian
Department of Study
School of Molecular & Cell Bio
Discipline
Biophysics & Computnl Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2012-02-06T20:17:43Z
Keyword(s)
  • domain
  • phylogeny
  • orthology
  • domain-based
Abstract
Domain-based approaches are used in phylogenetic reconstruction and functional identification. Two groups of ionotropic glutamate receptors (iGluR’s) were identified with the topology of the binding core and pore-loop of the eukaryotic iGluR’s. Group 1 has a potassium-like selectivity filter and Group 2 is most closely related to eukaryotic iGluR’s. The relationship among them was investigated in this research. Then, the domain complexity of proteins was analysed on a comprehensive basis. Our results showed that bacterial and archaeal proteins are as complex as eukaryotic proteins in domain abundance, but more promiscuous. Proteins emerged in early stage are also more promiscuous, but with low domain abundance. The possible application of protein comparison based on domain content was also suggested in this research and could be used to help the identification of function and orthology. Therefore, domain-based approaches are proved to be useful in many areas of proteome research, including functional annotation, evolutionary illustration, and protein-protein network construction.
Graduation Semester
2011-12
Permalink
http://hdl.handle.net/2142/29798
Copyright and License Information
Copyright 2011 Mao-Feng Ger

Owning Collections

Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois
Dissertations and Theses - Biophysics and Quantitative Biology