This is a review article on modeling convective flows due to either buoyancy force or surface tension gradient force during protein crystallization that have been studied in the past. The modeling and computational studies of such flows have provided useful results about the effects of the undesirable convection, which need to be minimized in order to produce protein crystal with higher quality and better order in the structure. Ramachandran et al. developed analytical and numerical models to describe the flows and transport associated with the protein crystal growth. Lee and Chernov carried out analytical and numerical studies of convective and diffusional mass transport to an isolated protein crystal growing from solution, with slow linear interface kinetics. Very recent modeling and computational studies by Bhattacharjee and Riahi of compositional convection during protein crystallization and under the external constraint of rotation indicated beneficial effects of rotation in reducing the effect of convection under certain range of the parameters values. The results by these authors also provided conditions under which convective flow transport during the protein crystallization can approach the diffusion limited transport, which is desirable for the production of higher quality protein crystals.
Publisher
Department of Theoretical and Applied Mechanics (UIUC)
TAM technical reports include manuscripts intended for publication, theses judged to have general interest, notes prepared for short courses, symposia compiled from outstanding undergraduate projects, and reports prepared for research-sponsoring agencies.
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