Instrumentation for a distributed feedback laser biosensor system
Chu, Allen C.
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https://hdl.handle.net/2142/26150
Description
Title
Instrumentation for a distributed feedback laser biosensor system
Author(s)
Chu, Allen C.
Issue Date
2011-08-25T22:16:22Z
Director of Research (if dissertation) or Advisor (if thesis)
Cunningham, Brian T.
Department of Study
Electrical & Computer Eng
Discipline
Electrical & Computer Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Distributed Feedback Laser
Biosensor
Instrumentation
Biochemical Assay
Label Free
Biomolecular Detection
Small Molecule Interaction
Abstract
The development of the instrumentation behind a biosensor system based on a vertically emitting distributed feedback laser is presented. The performance of the label-free high-resolution biomolecular detection system is optimized for use in applications that require the study of large quantities of parallel interactions that could be adversely affected by the use of molecular labels, such as high-throughput pharmaceutical drug screenings. A series of filtering and averaging methods for minimizing the effects of sensor noise are discussed in the analysis of both single spectrum measurements and kinetic scans over time. An example biochemical assay is performed to demonstrate and evaluate the current capabilities of the biosensor system. Plans for the future advancement of the system, including the possibilities of hardware improvements, device fabrication refinements, data analysis enhancements, and new usage models, are considered.
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