Inflammation enhanced colon cancer & natural anti-cancer plant compounds

Butler, Shannon M.

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https://hdl.handle.net/2142/24175 Copy

Description

Title

Inflammation enhanced colon cancer & natural anti-cancer plant compounds

Author(s)

Butler, Shannon M.

Issue Date

2011-05-25T14:59:14Z

Director of Research (if dissertation) or Advisor (if thesis)

Jeffery, Elizabeth H.

Department of Study

Food Science & Human Nutrition

Discipline

Food Science & Human Nutrition

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• Broccoli
• broccoli sprouts
• sulforaphane
• azoxymethane
• colon cancer
• inflammation
• dextran sulfate sodium
• Gymnaster koraiensis
• gymnasterkoreayne B
• polyacetylene

Abstract

Inflammation is associated with an increased risk for colorectal cancer through mechanisms that are not well understood. Isothiocyanates, which are the bioactive components in broccoli and other cruciferous vegetables, have been shown to suppress COX-2 and IL-6 production from inflammation. The polyacetylene gymnasterkoreayne B (GKB) was previously shown to increase detoxification enzymes, but has not previously been tested for anti-cancer activity (1). Here we tested 10% broccoli, 5% broccoli sprouts, GKB and a GKB-rich extract from Gymnaster koriensis (GE) for their ability to prevent inflammation-enhanced colon cancer, using the dextran sulfate sodium/ azoxymethane mouse model. GKB (500 µmol/kg diet daily), GE (providing an equal dose of GKB) and broccoli protected against some aspects of inflammation, including cyclooxygenase-2 levels in colonic mucosa. The extract and the 10% broccoli diet, but not purified GKB or 5% broccoli sprouts, protected against colon cancer, decreasing adenocarcinomas by 90%. These data suggest that the Gymnaster extract and broccoli are both promising anti-cancer products.

Graduation Semester

2011-05

Permalink

http://hdl.handle.net/2142/24175

Copyright and License Information

Copyright 2011 Shannon M. Butler

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